Sandboxie (free) is a Windows application that offers you a sandbox environment to run applications is. This can be very useful when doing any sort of application testing, as you can isolate it from the rest of the system.
Sandboxie offers environments for 64bit programs as well. Once you are finished with your sandbox session, you can empty the sandbox by right clicking on the system tray icon, selecting a sandbox you wish to empty, and selecting “Delete Contents”. You can also use “Quick Recovery” to move files from the sandbox to your system.